c-Myc is activated via USP2a-mediated modulation of microRNAs in prostate cancer
نویسندگان
چکیده
c-Myc is activated via USP2a-mediated modulation of microRNAs in prostate cancer Barbara Benassi*, Richard Flavin*, Luigi Marchionni, Silvio Zanata, Yunfeng Pan, Dipanjan Chowdhury, Marina Marani, Sabrina Strano, Paola Muti, Giovanni Blandino° & Massimo Loda°. Author’s Affiliations: Translational Oncogenomics Unit, Regina Elena Cancer Institute, Rome, Italy.Laboratory of Toxicology, ENEA-Casaccia, Rome, Italy. Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Department of Oncology, The John Hopkins Medical Institutions, Baltimore, Maryland, USA.Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Department of Basic Pathology and Cell Biology, Universidade Federal do Paraná, Brazil. Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.Department of Epidemiology, Regina Elena Cancer Institute, Rome, Italy. The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Division of Cancer Studies, King’s College, London School of Medicine, London, UK.
منابع مشابه
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
UNLABELLED Ubiquitin-specific protease 2a (USP2a) is overexpressed in almost half of human prostate cancers and c-Myc is amplified in one third of these tumor types. Transgenic MYC expression drives invasive adenocarcinomas in the murine prostate. We show that overexpression of USP2a downregulates a set of microRNAs that collectively increase MYC levels by MDM2 deubiquitination and subsequent p...
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